Rassignal triggersβ-Amyloid Precursor Protein(APP) expression
نویسندگان
چکیده
منابع مشابه
Amyloid Precursor Protein
Intracellular trafficking and proteolytic processing of amyloid precursor protein (APP) have been the focus of numerous investigations over the past two decades. APP is the precursor to the amyloid -protein (A ), the 38–43-amino acid residue peptide that is at the heart of the amyloid cascade hypothesis of Alzheimer disease (AD). Tremendous progress has been made since the initial identificatio...
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Amyloidprecursor protein (APP), a type I membrane protein, is physiologically processed by or -secretases that cleave APP N-terminal to the transmembrane region. Extracellular -cleavage of APP generates a large secreted N-terminal fragment, and a smaller cellular C-terminal fragment. Subsequent -secretase cleavage in the transmembrane region of the C-terminal fragment induces secretion of small...
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how to cite this article: bhadbhade a, cheng dw. amyloid precursor protein processing in alzheimer’s disease. iranian journal of child neurology2012;6(1):1-5. alzheimer’s disease (ad) is a progressive neurodegenerative disorder and a leading cause of dementia. the ad is characterized by presence of intraneuronal tangles and extracellular plaques in the brain. the plaques are composed of dense a...
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Amyloid plaques in Alzheimer’s disease contain 0-amyloid, encoded by portions of exons 16 and 17 of the amyloid precursor protein. The specific association of rare amyloid precursor protein mutations with some kindreds with early-onset familial Alzheimer’s disease suggests that specific abnormalities in amyloid precursor protein may contribute to the pathogenesis of Alzheimer’s disease. Until n...
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Alzheimer’s disease (AD) is today the most common form of dementia. It is a neurodegenerative disorder which is histopathologically characterised by amyloid plaques and neurofibrillary tangles. Amyloid plaques consist of the amyloid β-peptide (Aβ) that can form aggregates in the brain. Aβ is generated from the amyloid precursor protein (APP) through proteolytic cleavage. APP belongs to a conser...
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ژورنال
عنوان ژورنال: Small GTPases
سال: 2013
ISSN: 2154-1248,2154-1256
DOI: 10.4161/sgtp.24768